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boldenone undecylenate

Diseases of the central nervous system of various origins, especially those related to cardiovascular diseases and disorders of metabolic processes in the brain, intoxication (particularly in post-traumatic conditions and phenomena of chronic cerebrovascular insufficiency), accompanied by the deterioration of intellectual-mental functions, reduction of motor activity;

Neurotic condition manifested boldenone undecylenate apathy, increased exhaustion, decreased psychomotor activity, in violation of attention, memory impairment;

Violations of learning processes ; depression of mild to moderate severity ; Psihorganicheskie syndromes that appear intellectual and memory impairment and apatiko-abulicheskimi phenomena and vyaloapaticheskih state in schizophrenia;

Spasmodic state ;

Obesity (alimentary constitutional genesis);

Prevention of hypoxia , increase resistance to stress, functional correction of the body under extreme conditions of professional activity in order to prevent the development of fatigue and increase mental and physical performance, the correction of circadian biorhythm cycle inversion “sleep-wake”;

Chronic alcoholism (to reduce fatigue phenomena, depression, intellectual-mental disorders).

CONTRAINDICATIONS

Individual intolerance.

PRECAUTIONARY MEASURES

Fenotropil used with caution in patients with severe organic lesions of the liver and kidneys, severe arterial hypertension, in patients with atherosclerosis, and patients who have had previous panic attacks, anxiety raptoidnye state or acute psychotic states, especially agitated, because of the possibility of anxiety exacerbation, panic, hallucinations and delusions, as well as in patients who are prone to allergic reactions to nootropics pyrrolidone group.

USE IN PREGNANCY AND LACTATION

Fenotropil should not be used during boldenone undecylenate pregnancy and breastfeeding due to lack of clinical trial data.

USE IN PEDIATRICS

Not recommended the appointment phenotropil children, due to lack of data of the drug in children.

DOSAGE AND ADMINISTRATION

Fenotropil administered orally, immediately after a meal. The dose and duration of treatment should be determined by your doctor. Doses vary depending on the characteristics of the patient. The average single dose of 150 mg (from 100 mg to 250 mg); average daily dose of 250 mg (from 200 mg to 300 mg). The maximum tolerated dose of – 750 mg per day. It is recommended to divide the daily dose into 2 doses. The daily dose to 100 mg taken once in the morning, and more than 100 mg daily dose is divided into two stages. Duration of treatment may range from 2 weeks to 3 months. The average duration of treatment is 30 days. If necessary, the course may be repeated after a month.

To improve performance – 100-200 mg once in the morning for 2 weeks (for athletes – 3 days).

The recommended duration of treatment for patients with alimentary-constitutional obesity is 30-60 days at a dose of 100-200 mg once daily (in the morning).

Do not take Fenotropil later than 15 hours.

SIDE EFFECT

Insomnia (in case of the drug within 15 hours). Some patients in the first 1-3 days of the drug agitation may occur, flushing of the skin, a feeling of warmth, increased blood pressure.

OVERDOSE

No cases of overdose were reported. Treatment: symptomatic therapy.

Interaction with other drugs

Fenotropil may increase the effects of drugs that stimulate the central nervous system, antidepressants, and neuroprotective drugs.

SPECIAL INSTRUCTIONS

When excessive psycho-emotional exhaustion on the background of chronic stress and fatigue, chronic insomnia, acute administration boldenone undecylenate phenotropil the first day can cause a sharp need for sleep. Such patients on an outpatient basis should be advised to start taking the drug in exchange holidays.

equipoise definition

Equipoise definition – nootropic drug has a pronounced antiamnestic action has a direct activating effect on the integrative activity of the brain contributes to memory consolidation, improves concentration and mental performance, facilitates the learning process, increases the speed of information transfer between the hemispheres of the brain, increases resistance to brain tissue hypoxia and toxic effects, possesses anticonvulsant action and anxiolytic activity, regulates the processes of the central nervous system activation and inhibition, improves mood.

Fenotropil has a positive effect on the metabolism and blood circulation of the brain, stimulates the redox processes, improves the body’s energy potential due to glucose utilization, improves regional blood flow in ischemic areas of the brain. Increases of noradrenaline, dopamine and serotonin in the brain, does not affect the levels of GABA, is not associated with either  receptor has no noticeable effect on the spontaneous bioelectric activity of the brain.

Fenotropil no effect on respiration and the cardiovascular system, displays unspoken diuretic effect , it has anoreksigennoy activity in exchange application.

Phenotropil stimulating effect manifested in its ability to provide a moderately pronounced effect on motor reactions in improving physical performance, expressed antagonism cataleptic effects of neuroleptics and also in reducing the severity of hypnotic action of ethanol and hexenal.

Stimulating effect phenotropil ideatornoy prevails in the area . Moderate inducing effect of the drug is combined with anxiolytic activity, improves mood, has some analgesic effect by raising the pain threshold.

Phenotropil adaptogenic effect is to increase the body’s resistance to stress under conditions of excessive mental and physical stress, with fatigue, hypokinesia and immobilization at low temperatures.

While taking phenotropil marked improvement in vision, which is reflected in an increase in sharpness, brightness and field of view.

Fenotropil improves blood flow equipoise definition to the lower extremities.

Phenotropil stimulate antibody production in response to antigen indicating its immunostimulatory properties, but at the same time it does not promote immediate hypersensitivity and allergic inflammatory changes of the skin reaction induced by the introduction of the foreign protein.

In exchange application phenotropil not develop drug dependence, tolerance and “withdrawal syndrome”.

Action phenotropil seen with a single dose, which is important when using the drug in extreme conditions.

Fenotropil has no teratogenic, mutagenic, carcinogenic and embryotoxic properties. Toxicity – low lethal dose in the acute experiment is 800 mg / kg.

Pharmacokinetics.

Fenotropil rapidly absorbed, it equipoise definition penetrates into the various organs and tissues, readily passes through the blood-brain barrier. The absolute bioavailability after oral administration is 100%. Maximum concentration in blood reached after 1 hour half-life of 3-5 hours. Fenotropil not metabolized by the body and excreted from the body unchanged. Approximately 40% of the drug is excreted in urine and 60% of the drug is excreted in the bile and sweat.

 

equipoise steroid

Stable under acidic conditions. The absorption in the small intestine – 30-60% bond to plasma proteins – 60-80%, continuously circulates in the blood, slowly penetrates the tissue. High concentrations are determined in the kidney, lower – in the liver, small intestine wall skin. Therapeutic blood equipoise steroid levels after oral administration are achieved after 30 min, and stored 3-6 hours. It is metabolized in the liver of 30-35%. The half – 30-45 minutes and is prolonged in infants, elderly patients, renal nedostochnosti. Excreted unchanged (25%) in the form of metabolites (35%), about 30% of the feces c.

 

Indications
Infections of the upper and lower respiratory tract infections (bronchitis, pneumonia), upper respiratory tract (tonsillitis, laryngitis, otitis media, sinusitis), mouth (a bacterial disease, periodontal disease, actinomycosis), skin and soft tissue (abscess, cellulitis, erysipelas , contagious impetigo, erythema migrans, abrasions, pseudoerysipelas); gonorrhea, syphilis, tetanus, anthrax, botulism, scarlet fever, leptospirosis, diphtheria, inflammation of lymph nodes (lymphadenitis);prevention of bacterial infections after surgery in frail patients, recurrence of rheumatic fever, bacterial endocarditis, rheumatic fever, chorea minor.

Contraindications:
Hypersensitivity (including to other beta-lactam antibiotics -. Penicillins, cephalosporins, carbapenems), aphthous stomatitis and sore throat, severe infections, gastrointestinal disease, accompanied by vomiting and diarrhea.

Dosage
Inside for 0.5-1 hour before meals, washed down with copious amounts of fluid. Adults and children over 12 years: 500-1000 mg (1 mg – 1610 IU) 3-4 times a day.
In severe chronic renal failure the interval between doses increased to 12 hours The course of treatment – 5-7 days.; infections equipoise steroid caused by beta-hemolytic streptococcus – at least 7-10 days and 3 days after normalization of body temperature.
For children under 1 year – a daily dose of 20-30 mg / kg; 1-6 years – 15-30 mg / kg, 6-12 -10-20 mg / kg; daily dose divided into 4-6 receptions. Children under 3 years of appointment, preferably in the form of a solution or suspension.
For the prevention of rheumatic fever or chorea minor -. 500 mg 2 times a day
for the prevention of postoperative complications in adults and children weighing more than 30 kg for 0.5-1 hours before surgery is prescribed 2 g, followed by 0.5 g every 6 hours for 2 days.

Side effects
: Allergic reactions: hives, skin flushing, angioedema, rhinitis, conjunctivitis, rarely – fever, serum sickness, arthralgia, eosinophilia, rarely – anaphylactic shock.
From the side of hematopoiesis: hemolytic anemia, leukopenia, agranulocytosis, thrombocytopenia, pancytopenia.
from the digestive system: the dyspeptic disorders (nausea, vomiting, diarrhea), glossitis, stomatitis, vesicular cheilitis (related to the irritating effect of the drug on the mucous membranes), decreased appetite, dry mouth, taste disturbance, rarely pseudomembranous enterocolitis.
Others: interstitial nephritis , pharyngitis, vasculitis.

Interaction with other drugs
increases the effectiveness of indirect anticoagulants (suppressing the intestinal microflora, reduces the formation of vitamin K); reduces the effectiveness of oral contraceptives and medicines during the metabolism that produce para-aminobenzoic acid.
It increases the risk of bleeding equipoise steroid “breakthrough” while taking ethinyl estradiol.
Antacids, glucosamine, laxatives, food, aminoglycosides slow down and reduce absorption; ascorbic acid increases it.
The bactericidal antibiotics (including cephalosporin, cycloserine, vancomycin, rifampin), aminoglycosides – a synergy of action; bacteriostatic antibiotics (including macrolides, chloramphenicol, lincosamides, tetracyclines) -. antagonism
Diuretics, allopurinol, phenylbutazone, nonsteroidal anti-inflammatory analgesics, and other drugs that reduce tubular secretion, increase the concentration of penicillin.
Allopurinol increases the risk of allergic reactions (skin rash) .

Cautions
Prolonged or re-appointment may cause superinfection development, pathogens which are resistant bacteria or fungi.
If during treatment or during the first weeks after the cessation of severe persistent diarrhea occurs, pseudomembranous colitis equipoise steroid should be exclude

equipose

When administered slowly absorbed completely. The maximum plasma concentration is determined after 1-2 hours, the connection with plasma proteins – 50%, in infants – 30-40%. It is metabolized in the liver, induces hepatic microsomal enzymes equipose (the rate of enzymatic reactions is increased 10-12 times). It accumulates in the body. The half-life of 2-4 days. Excreted by the kidneys in the form of glucuronide, about 25% – unchanged. Penetrates into breast milk and through the placenta.

Indications

  • epilepsy (all types of seizures except absence seizures), non-epileptic seizures genesis;
  • chorea;
  • spastic paralysis;
  • sleep disturbances, agitation, anxiety, fear.

CONTRAINDICATIONS
Hypersensitivity to any component of the drug, severe hepatic and / or renal failure, drug dependency (including history), hyperkinesis, myasthenia gravis, severe anemia, porphyria, diabetes, hypoadrenalism, hyperthyroidism, depression, bronchial obstructive disease, active alcohol , pregnancy, lactation period. this dosage is not used in children because of the impossibility of accurately dosing (for children use tablets containing 5 mg or 50 mg of pentobarbital) .

Precautions
In debilitated patients (high risk of paradoxical excitation, depression, and confusion even in the appointment of the usual dose).

Dosage and administration
. Inside Adult :

  • sleep disorders: 100-200 mg for 0.5-1 hours before bedtime.
  • as a sedative medicinal product: 50 mg 2-3 times a day.
  • as an anticonvulsant: 50-100 mg 2 times a day.

By reducing liver function should be administered in smaller doses.

Side effect On the part of the equipose nervous system : asthenia, dizziness, weakness, ataxia, nystagmus, paradoxical reaction (especially in elderly and debilitated patients – excitement), hallucinations, depression, “nightmarish” dream, sleep disturbances, syncope. On the part of the musculoskeletal unit : long-term use – osteopenia and rickets development. From the digestive system : nausea, vomiting, constipation, long-term use – the liver. From the side of hematopoiesis : agranulocytosis, megaloblastic anemia, and thrombocytopenia. Since the cardiovascular system : lowering blood pressure. Allergic reactions : skin rash, hives, swelling of the eyelids, face and lips, shortness of breath, rarely – exfoliative dermatitis malignant exudative erythema {Stevens-Johnson syndrome). Other : long-term use – drug dependency.

 

Overdose Symptoms : nystagmus, ataxia, dizziness, headache, confusion, slurred speech, severe fatigue, decrease or loss of reflexes, severe drowsiness or agitation, increase or decrease in body temperature, respiratory depression, shortness of breath, decreased blood pressure, constriction of the pupils (alternating with paralytic extension), oliguria, tachy or bradycardia, cyanosis, confusion, cessation of electrical activity in the brain, pulmonary edema, coma, and later – pneumonia, arrhythmia, heart failure; when taking 2-10 grams – death; in chronic toxicity – irritability, weakening of the capacity for critical evaluation, sleep disturbances, confusion. Treatment : No specific antidote. Gastric lavage, reception activated carbon, conducting detoxification therapy, symptomatic treatment, the maintenance of vital body functions.

Interaction with other drugs
phenytoin and phenobarbital valproate increases the content in blood serum. The anticonvulsant effect of phenobarbital decreases at the same time taking with reserpine, increases when combined with amitriptyline, nialamidom, diazepam, hlordiaazepoksidom.
Reduces the effectiveness of oral contraceptives and salicylates.
Decreases in blood levels of anticoagulants, corticosteroids, griseofulvin, doxycycline, estrogens and other drugs metabolized in liver by oxidation pathway (accelerates their destruction).
Enhances the effects of alcohol, neuroleptics, narcotic analgesics, muscle relaxants, sedatives and hypnotics.
Acetazolamide, oschelachivaya urine equipose reduces the reabsorption of phenobarbital in the kidneys and weakens its effect.
phenobarbital calming effect is reduced while taking atropine, herb extract, dextrose, thiamine, niacin, analeptikami and psycho-stimulant drugs.
Reduces the antibacterial activity of antibiotics and sulfonamides, anti-fungal effect of griseofulvin.

Cautions
Avoid prolonged use of the drug because of the possibility of its accumulation in the body and the development of addiction.
In order to avoid the syndrome of “lifting” (headache, “nightmarish” dream, drowsiness, and / or insomnia) to stop the treatment should be gradual.
During treatment, not recommended driving and exercise activities that require speed of psychomotor reactions.

Form release
tablets 100 mg. On 6 tablets in contour bezgyachakova container or 10 tablets in blisters. 1 contour bezgyachakova packaging or 1 or 2 blisters with instruction on use in a pile of cardboard.

boldenone

When applied topically penetrates well into the skin; systemic bioavailability – 10%. Pruritus of different origin boldenone (except associated with cholestasis), for example, itchy dermatitis, eczema, urticaria, insect bites.
Sunburn, household and industrial burns (mild). Hypersensitivity to dimetindenu and other components of the drug, angle-closure glaucoma, prostatic hyperplasia, children under the age of 1 month, especially premature.

Precautions – Pregnancy Trimester 1, lactation.

Pregnancy and lactation:
Use of the drug in the first three months of pregnancy is possible only after consultation with your doctor. In II and III trimesters of pregnancy and lactation Fenistil gel should not be used on large areas of skin, especially in the presence of inflammation or bleeding phenomena. Nursing mothers boldenone should not be applied in the preparation of the nipples of mammary glands.

Dosage and administration:

Outwardly. The gel is applied to the affected area 2-4 times a day. In cases of pronounced itching or skin lesions common to the simultaneous use of oral forms.

Side effects

Dry, burning of the skin. In rare cases – skin rash and itching.

Overdose:

cases of overdose have not been described.

Interactions: not described.

special instructions

In infants and young children should not use the drug to large areas of skin, especially in the presence of phenomena of inflammation or bleeding.
In marked itching or extensive lesions of the skin preparation may be used only after consulting a doctor.
When using the gel Fenistil on large areas of skin should be avoid exposure to sunlight.
If the severity of symptoms of the disease is not reduced in the period of application of fenistil gel or, on the contrary, boldenone intensified, it is necessary to consult a doctor.
Ineffective pruritus associated with cholestasis.

Product form:

Gel for topical application in 30 g aluminum tubes with a polypropylene lid. Tuba, together with instructions for use are packed in a cardboard box.