A means for the treatment and prevention of iron deficiency
drug contains as active ingredients ferrous fumarate and folic acid. Iron fumarate – an iron salt, a trace element necessary for the synthesis of hemoglobin. When using iron in the form of salts, there is a rapid replenishment of its deficiency in the body, which leads to a gradual regression of clinical (weakness, fatigue, dizziness, tachycardia, pain and dryness of the skin) and laboratory symptoms of anemia. Folic acid is essential for normal maturation and education megaloblasts normoblasts. It stimulates erythropoiesis, is involved in the synthesis of amino acids, nucleic acids, purine and pyrimidine metabolism in choline. During pregnancy protects the body from the effects of teratogens. Eq steroid contributes to the maintenance and restoration of normal levels of iron in the blood and prevents complications such as anemia, miscarriage, early labor and violation of children’s mental development, which can be observed with a deficiency of iron and folic acid in the body. The amount of assimilable iron is between 5 and 35%.
The serum transferrin bound iron and is involved in the formation of hemoglobin, myoglobin, cytochrome oxidase, catalase and peroxidase or stored in body tissues in the form of ferritin.
iron allocation occurs in the feces, urine and sweat. Folic acid is absorbed primarily in the upper gastrointestinal tract (duodenum) and 64% bound proteins. Folic acid is metabolized in the liver and excreted primarily through the kidneys and partially with faeces.
Treatment and prevention of iron deficiency caused by pregnancy, impaired iron absorption from the gastrointestinal tract, prolonged bleeding, malnutrition and unbalanced.
Hypersensitivity to the drug. Diseases accompanied by accumulation of iron in the body (aplastic and haemolytic anemia, thalassemia, hemosiderosis, hemochromatosis). Violation of the absorption of iron (sideroahrestical anemia, lead anemia, pernicious anemia (vitamin B12 deficiency). The anemia that is not caused by iron deficiency or folic acid.
Dosing and Administration
Ferretab COMP taken orally, 1 capsule per day on an empty stomach, abundant with some liquid. When expressed iron deficiency or folic acid dose should be increased to two or three capsules a day.Maintenance eq steroid treatment should be continued for at least 4 weeks after the normal hemoglobin level for the normalization of serum ferritin, which reflects iron stores in the body.
Ferretab COMP is well tolerated by patients.
In some cases there may be a temporary adverse effect on the gastrointestinal tract (feeling of fullness and discomfort in the stomach, nausea, vomiting), and allergic reactions, constipation.
Symptoms – possibly increasing incidence described side effects. If you suspect an overdose, it is necessary to conduct a study of serum iron and serum ferritin levels. In the event of a significant excess of normal values of serum ferritin should be the appointment of iron chelator (Desferal) in accordance with the recommended dose of the manufacturer.
Interaction with other drugs
When concomitantly with antacids eq steroid iron absorption worsens.
Simultaneous treatment with ascorbic acid improves iron absorption.
Avoid joint use with antibiotics of the tetracycline group in connection with the violation of iron absorption. Kolestiramin, phenytoin, phenobarbital, carbamazepine, sulfasalazine, hormonal contraceptives, folic acid antagonists, trimethoprim, triamterene, solid food, bread, raw cereals, dairy products, eggs, tea reduces iron absorption.
Before therapy of iron supplementation is necessary to conduct a study of serum iron, serum ferritin (ie documented iron deficiency).
Therapy Ferretab COMP should be done to normalize the blood picture (8-12 weeks).
Before the drug can be dark fecal staining, benzidine test – false-positive.
Use during pregnancy and lactation
Perhaps the during pregnancy and during breast-feeding when indicated